This assay quantifies a selected protein within the blood liable for transporting glucocorticoid hormones, equivalent to cortisol. This protein performs an important position in regulating the bioavailability of those hormones, influencing their exercise in numerous tissues. For instance, low ranges of this protein can lead to greater ranges of free, unbound cortisol, probably resulting in scientific manifestations of hypercortisolism even when complete cortisol ranges seem regular. Conversely, elevated ranges can lower free cortisol, mimicking hypocortisolism.
Measurement of this protein is clinically important as a result of it aids within the correct evaluation of glucocorticoid standing. Its ranges are affected by a wide range of circumstances, together with being pregnant, liver illness, thyroid problems, and genetic components. Understanding its focus contributes to the right analysis and administration of endocrine problems, significantly these associated to adrenal perform. Traditionally, evaluation of adrenal perform relied closely on complete cortisol measurements; nonetheless, recognizing the affect of this binding protein has refined diagnostic approaches.